Highly Efficient Mono-Functionalization of Knob-in-Hole Antibodies with Strain-Promoted Click Chemistry

[Image: see text] Knob-in-hole antibodies can be utilized to introduce a single tag for chemo-enzymatic functionalization. By either introducing a single C-terminal sortase tag (sortase-tag expressed protein ligation) or tyrosine tag (G(4)Y), mono-functionalization of the monoclonal antibody trastuz...

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Detalles Bibliográficos
Autores principales: Bruins, Jorick J., van de Wouw, Criss, Wagner, Koen, Bartels, Lina, Albada, Bauke, van Delft, Floris L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682001/
https://www.ncbi.nlm.nih.gov/pubmed/31460288
http://dx.doi.org/10.1021/acsomega.9b01727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682001/
https://www.ncbi.nlm.nih.gov/pubmed/31460288
http://dx.doi.org/10.1021/acsomega.9b01727

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