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Structural Basis and Mechanism for Vindoline Dimers Interacting with α,β-Tubulin
[Image: see text] Vinblastine and its derivatives used in clinics as antitumor drugs often cause drug resistance and some serious side effects; thus, it is necessary to study new vinblastine analogues with strong anticancer cytotoxicity and low toxicity. We designed a dimer molecule using two vindol...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682054/ https://www.ncbi.nlm.nih.gov/pubmed/31460305 http://dx.doi.org/10.1021/acsomega.9b00947 |