Cargando…

Taar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1

We identified a locus on mouse chromosome 10 that accounts for 60% of the genetic variance in methamphetamine intake in mice selectively bred for high versus low methamphetamine consumption. We nominated the trace amine-associated receptor 1 gene, Taar1, as the strongest candidate and identified reg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stafford, Alexandra M, Reed, Cheryl, Baba, Harue, Walter, Nicole AR, Mootz, John RK, Williams, Robert W, Neve, Kim A, Fedorov, Lev M, Janowsky, Aaron J, Phillips, Tamara J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682400/ https://www.ncbi.nlm.nih.gov/pubmed/31274109 http://dx.doi.org/10.7554/eLife.46472

Ejemplares similares

Confirmation of a Causal Taar1 Allelic Variant in Addiction-Relevant Methamphetamine Behaviors
por: Phillips, Tamara J., et al.
Publicado: (2021)

A Spontaneous Mutation in Taar1 Impacts Methamphetamine-Related Traits Exclusively in DBA/2 Mice from a Single Vendor
por: Reed, Cheryl, et al.
Publicado: (2018)

Regional Analysis of the Brain Transcriptome in Mice Bred for High and Low Methamphetamine Consumption
por: Hitzemann, Robert, et al.
Publicado: (2019)

A Mouse Model for Binge-Level Methamphetamine Use
por: Shabani, Shkelzen, et al.
Publicado: (2016)

Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors
por: Glyakina, Anna V., et al.
Publicado: (2021)

Structural and Functional Evolution of the Trace Amine-Associated Receptors TAAR3, TAAR4 and TAAR5 in Primates
por: Stäubert, Claudia, et al.
Publicado: (2010)

Identification and characterization of cichlid TAAR genes and comparison with other teleost TAAR repertoires
por: Azzouzi, Naoual, et al.
Publicado: (2015)

TAAR1 dependent and independent actions of the potential antipsychotic and dual TAAR1/5-HT(1A) receptor agonist SEP-363856
por: Saarinen, Marcus, et al.
Publicado: (2022)

Correction To: TAAR1 dependent and independent actions of the potential antipsychotic and dual TAAR1/5-HT(1A) receptor agonist SEP- 363856
por: Saarinen, Marcus, et al.
Publicado: (2022)

TAAR1 in Addiction: Looking Beyond the Tip of the Iceberg
por: Liu, Jian-Feng, et al.
Publicado: (2018)

Ulotaront: A TAAR1 Agonist for the Treatment of Schizophrenia
por: Heffernan, Michele L. R., et al.
Publicado: (2021)

Behavioral Effects of a Potential Novel TAAR1 Antagonist
por: Lam, Vincent M., et al.
Publicado: (2018)

Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types
por: Salimando, Gregory J., et al.
Publicado: (2023)

Analysis of Human TAAR8 and Murine Taar8b Mediated Signaling Pathways and Expression Profile
por: Mühlhaus, Jessica, et al.
Publicado: (2014)

Taare Zameen Par and dyslexic savants
por: Chakravarty, Ambar
Publicado: (2009)

Trace Amine Associated Receptor 1 (TAAR1) Modulation of Food Reward
por: Moore, Catherine F., et al.
Publicado: (2018)

Investigation of Naturally Occurring Single-Nucleotide Variants in Human TAAR1
por: Mühlhaus, Jessica, et al.
Publicado: (2017)

The Case for TAAR1 as a Modulator of Central Nervous System Function
por: Rutigliano, Grazia, et al.
Publicado: (2018)

Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers
por: Fleischer, Lisa M., et al.
Publicado: (2018)

Elevated methylation of OPRM1 and OPRL1 genes in Alzheimer's disease
por: Xu, Chunshuang, et al.
Publicado: (2018)

Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs
por: Vallender, Eric J, et al.
Publicado: (2010)

Evaluation of Approach to a Conspecific and Blood Biochemical Parameters in TAAR1 Knockout Mice
por: Zhukov, Ilya S., et al.
Publicado: (2022)

Ulotaront: review of preliminary evidence for the efficacy and safety of a TAAR1 agonist in schizophrenia
por: Achtyes, Eric D., et al.
Publicado: (2023)

Association study of OPRM1 polymorphisms with Schizophrenia in Han Chinese population
por: Ding, Saidan, et al.
Publicado: (2013)

Lack of association between DRD2 and OPRM1 genotypes and adiposity
por: Hardman, C A, et al.
Publicado: (2014)

Role of OPRM1, clinical and anthropometric variants in neonatal pain reduction
por: Erbi, Ilaria, et al.
Publicado: (2020)

Dynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface
por: López, Cesar A., et al.
Publicado: (2017)

Biochemical and Functional Characterization of the Trace Amine-Associated Receptor 1 (TAAR1) Agonist RO5263397
por: Espinoza, Stefano, et al.
Publicado: (2018)

Effect of TAAR1/5-HT(1A) agonist SEP-363856 on REM sleep in humans
por: Hopkins, Seth C., et al.
Publicado: (2021)

Trace Amine-Associated Receptor 1 (TAAR1) Is a Positive Prognosticator for Epithelial Ovarian Cancer
por: Vogelsang, Tilman L. R., et al.
Publicado: (2021)

Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine
por: Zhang, Xiaoqun, et al.
Publicado: (2018)

Therapeutic Potential of TAAR1 Agonists in Schizophrenia: Evidence from Preclinical Models and Clinical Studies
por: Dedic, Nina, et al.
Publicado: (2021)

Improving Efficiency and Equity in Early Autism Evaluations: The (S)TAAR Model
por: Brinster, Meredith I., et al.
Publicado: (2022)

μ-Opioid receptor gene (OPRM1) polymorphism in patients with breast cancer
por: Cieślińska, Anna, et al.
Publicado: (2015)

Effect of short-term prescription opioids on DNA methylation of the OPRM1 promoter
por: Sandoval-Sierra, Jose Vladimir, et al.
Publicado: (2020)

Associations of the A118G OPRM1 polymorphism with sociotropy and interpersonal sensitivity
por: Suzuki, Akihito, et al.
Publicado: (2022)

Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence
por: Loftis, Jennifer M., et al.
Publicado: (2019)

Genome Sequence of Lecanicillium fungicola 150-1, the Causal Agent of Dry Bubble Disease
por: Banks, Alice M., et al.
Publicado: (2019)

TAAR1 induces a disturbed GSK3β phosphorylation in recurrent miscarriages through the ODC
por: Stavrou, Stavroula, et al.
Publicado: (2018)

Thyronamine regulation of TAAR1 expression in breast cancer cells and investigation of its influence on viability and migration
por: Tremmel, Eileen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_kg579b3dcd6dif1n9oieuu5j6k