A circuit-dependent ROS feedback loop mediates glutamate excitotoxicity to sculpt the Drosophila motor system

Overproduction of reactive oxygen species (ROS) is known to mediate glutamate excitotoxicity in neurological diseases. However, how ROS burdens can influence neural circuit integrity remains unclear. Here, we investigate the impact of excitotoxicity induced by depletion of Drosophila Eaat1, an astro...

Descripción completa

Detalles Bibliográficos
Autores principales: Peng, Jhan-Jie, Lin, Shih-Han, Liu, Yu-Tzu, Lin, Hsin-Chieh, Li, Tsai-Ning, Yao, Chi-Kuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682402/
https://www.ncbi.nlm.nih.gov/pubmed/31318331
http://dx.doi.org/10.7554/eLife.47372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682402/
https://www.ncbi.nlm.nih.gov/pubmed/31318331
http://dx.doi.org/10.7554/eLife.47372

Ejemplares similares