Subunit contribution to NMDA receptor hypofunction and redox sensitivity of hippocampal synaptic transmission during aging

We examined the contribution of N-methyl-D-aspartate receptor (NMDAR) subunits in the redox-mediated decline in NMDAR function during aging. GluN2A and GluN2B selective antagonists decreased peak NMDAR currents to a similar extent in young and aged animals, indicating that a shift in diheteromeric G...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Ashok, Thinschmidt, Jeffrey S., Foster, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682512/
https://www.ncbi.nlm.nih.gov/pubmed/31339863
http://dx.doi.org/10.18632/aging.102108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682512/
https://www.ncbi.nlm.nih.gov/pubmed/31339863
http://dx.doi.org/10.18632/aging.102108

Ejemplares similares