Cargando…

Subunit contribution to NMDA receptor hypofunction and redox sensitivity of hippocampal synaptic transmission during aging

We examined the contribution of N-methyl-D-aspartate receptor (NMDAR) subunits in the redox-mediated decline in NMDAR function during aging. GluN2A and GluN2B selective antagonists decreased peak NMDAR currents to a similar extent in young and aged animals, indicating that a shift in diheteromeric G...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Ashok, Thinschmidt, Jeffrey S., Foster, Thomas C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682512/ https://www.ncbi.nlm.nih.gov/pubmed/31339863 http://dx.doi.org/10.18632/aging.102108

Ejemplares similares

Contribution of NMDA Receptors to Synaptic Function in Rat Hippocampal Interneurons
por: Booker, Sam A., et al.
Publicado: (2021)

NMDA Receptor Hypofunction in the Aging-Associated Malfunction of Peripheral Tissue
por: Rivera-Villaseñor, Angélica, et al.
Publicado: (2021)

Contribution of NMDA Receptor Hypofunction in Prefrontal and Cortical Excitatory Neurons to Schizophrenia-Like Phenotypes
por: Rompala, Gregory R., et al.
Publicado: (2013)

Aberrant maturation and connectivity of prefrontal cortex in schizophrenia – contribution of NMDA receptor development and hypofunction
por: Gao, Wen-Jun, et al.
Publicado: (2022)

12.2 METABOLIC CONSEQUENCES OF DEVELOPMENTAL NMDA RECEPTOR HYPOFUNCTION
por: Funk, Adam, et al.
Publicado: (2018)

Spatial and temporal boundaries of NMDA receptor hypofunction leading to schizophrenia
por: Nakazawa, Kazu, et al.
Publicado: (2017)

A circuit mechanism for decision-making biases and NMDA receptor hypofunction
por: Cavanagh, Sean Edward, et al.
Publicado: (2020)

Premature commitment to uncertain decisions during human NMDA receptor hypofunction
por: Salvador, Alexandre, et al.
Publicado: (2022)

The Effects of NR2 Subunit-Dependent NMDA Receptor Kinetics on Synaptic Transmission and CaMKII Activation
por: Santucci, David M., et al.
Publicado: (2008)

The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms
por: Incontro, Salvatore, et al.
Publicado: (2018)

Changes in NMDA receptor contribution to synaptic transmission in the brain in a rat model of glaucoma
por: Georgiou, A.L., et al.
Publicado: (2010)

Vulnerability to omega-3 deprivation in a mouse model of NMDA receptor hypofunction
por: Islam, Rehnuma, et al.
Publicado: (2017)

The cannabinoid receptor 1 associates with NMDA receptors to produce glutamatergic hypofunction: implications in psychosis and schizophrenia
por: Sánchez-Blázquez, Pilar, et al.
Publicado: (2014)

Altered Excitatory-Inhibitory Balance in the NMDA-Hypofunction Model of Schizophrenia
por: Kehrer, Colin, et al.
Publicado: (2008)

NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia
por: Snyder, Melissa A., et al.
Publicado: (2013)

Schizophrenia-Like Dopamine Release Abnormalities in a Mouse Model of NMDA Receptor Hypofunction
por: Nakao, Kazuhito, et al.
Publicado: (2019)

Altered neural oscillations and behavior in a genetic mouse model of NMDA receptor hypofunction
por: Aguilar, David D., et al.
Publicado: (2021)

Author Correction: The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms
por: Incontro, Salvatore, et al.
Publicado: (2018)

Dual orexin/hypocretin receptor antagonism attenuates attentional impairments in an NMDA receptor hypofunction model of schizophrenia
por: Maness, Eden B., et al.
Publicado: (2023)

NMDA Receptors Contribute to Retrograde Synaptic Transmission from Ganglion Cell Photoreceptors to Dopaminergic Amacrine Cells
por: Liu, Lei-Lei, et al.
Publicado: (2017)

Neonatal NMDA Receptor Blockade Disrupts Spike Timing and Glutamatergic Synapses in Fast Spiking Interneurons in a NMDA Receptor Hypofunction Model of Schizophrenia
por: Jones, Kevin S., et al.
Publicado: (2014)

T‐type calcium channels contribute to NMDA receptor independent synaptic plasticity in hippocampal regular‐spiking oriens‐alveus interneurons
por: Nicholson, Elizabeth, et al.
Publicado: (2017)

GluN2 Subunit-Dependent Redox Modulation of NMDA Receptor Activation by Homocysteine
por: Sibarov, Dmitry A., et al.
Publicado: (2020)

NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss
por: Tackenberg, C, et al.
Publicado: (2013)

NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition
por: Baez, María Verónica, et al.
Publicado: (2018)

5-HT2A receptor dysregulation in a schizophrenia relevant mouse model of NMDA receptor hypofunction
por: Nakao, Kazuhito, et al.
Publicado: (2022)

NMDA Receptor Hypofunction Leads to Generalized and Persistent Aberrant γ Oscillations Independent of Hyperlocomotion and the State of Consciousness
por: Hakami, Tahir, et al.
Publicado: (2009)

Ketamine: Linking NMDA receptor hypofunction, gamma oscillations and psychosis (commentary on Qin et al., 2022)
por: Reilly, Thomas J.
Publicado: (2022)

Subunit-specific NMDAR antagonism dissociates schizophrenia subtype-relevant oscillopathies associated with frontal hypofunction and hippocampal hyperfunction
por: Pittman-Polletta, Benjamin, et al.
Publicado: (2018)

Modulation of GABAergic Synaptic Transmission by NMDA Receptors in the Dorsal Horn of the Spinal Cord
por: Leonardon, Benjamin, et al.
Publicado: (2022)

Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors
por: Park, Hyungju, et al.
Publicado: (2015)

Decision Making in Mice During an Optimized Touchscreen Spatial Working Memory Task Sensitive to Medial Prefrontal Cortex Inactivation and NMDA Receptor Hypofunction
por: Dexter, Tyler D., et al.
Publicado: (2022)

PM368. Ketogenic diet normalises schizophrenia-like behaviours in acute and chronic NMDA-receptor hypofunction models
por: Kraeuter, Ann-Katrin, et al.
Publicado: (2016)

Fragile-X Syndrome Is Associated With NMDA Receptor Hypofunction and Reduced Dendritic Complexity in Mature Dentate Granule Cells
por: Yau, Suk-Yu, et al.
Publicado: (2019)

Acute 5-HT7 receptor activation increases NMDA-evoked currents and differentially alters NMDA receptor subunit phosphorylation and trafficking in hippocampal neurons
por: Vasefi, Maryam S, et al.
Publicado: (2013)

PM372. Functional change of serotonin 2C receptors in N-Methyl-D-aspartate (NMDA) receptor hypofunctional condition
por: Tsutsumi, Takahiro, et al.
Publicado: (2016)

Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition
por: Franchini, Luca, et al.
Publicado: (2019)

Target cell-specific plasticity rules of NMDA receptor-mediated synaptic transmission in the hippocampus
por: Lutzu, Stefano, et al.
Publicado: (2023)

Correction to: Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors
por: Park, Hyungju, et al.
Publicado: (2021)

Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes
por: Kortus, Stepan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_rtjh5urauhrlunriecae9i2a5b