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Immune system development and age-dependent maintenance in Klotho-hypomorphic mice

Circulating Klotho peptide hormone has anti-aging activity and affects tissue maintenance. Hypomorphic mutant Klotho [kl/kl] mice on C57BL/6xC3H, BALB/c and 129 genetic backgrounds, show decreased Klotho expression that correlate with accelerated aging including pre-mature death due to abnormally hi...

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Detalles Bibliográficos
Autores principales: Zhu, Wandi Sandra, Naler, Lynette, Maul, Robert W., Sallin, Michelle A., Sen, Jyoti Misra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682518/
https://www.ncbi.nlm.nih.gov/pubmed/31386628
http://dx.doi.org/10.18632/aging.102121