Increased susceptibility to mammary carcinogenesis and an opposite trend in endometrium in Trp53 heterozygous knockout female mice by backcrossing the BALB/c strain onto the background C3H strain

Patients with dominantly inherited Li-Fraumeni syndrome have a loss-of-function mutation in TP53 and develop diverse mesenchymal and epithelial neoplasms at multiple sites. Trp53(+/−) female mice with the BALB/c background provide unique characteristics for the study of breast cancer in Li-Fraumeni...

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Detalles Bibliográficos
Autores principales: Machida, Yukino, Sudo, Yukiko, Uchiya, Naoaki, Imai, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682560/
https://www.ncbi.nlm.nih.gov/pubmed/31404346
http://dx.doi.org/10.1293/tox.2018-0057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682560/
https://www.ncbi.nlm.nih.gov/pubmed/31404346
http://dx.doi.org/10.1293/tox.2018-0057

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