Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes

Enzymes of the cytochrome P450 (CYP) subfamily 3A and 2C play a major role in the metabolism of taxane anticancer agents. While their function in hepatic metabolism of taxanes is well established, expression of these enzymes in solid tumors may play a role in the in situ metabolism of drugs as well,...

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Detalles Bibliográficos
Autores principales: van Eijk, Maarten, Boosman, René J., Schinkel, Alfred H., Huitema, Alwin D. R., Beijnen, Jos H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682574/
https://www.ncbi.nlm.nih.gov/pubmed/31309254
http://dx.doi.org/10.1007/s00280-019-03905-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682574/
https://www.ncbi.nlm.nih.gov/pubmed/31309254
http://dx.doi.org/10.1007/s00280-019-03905-3

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