Enhanced Activity and Substrate Specificity by Site‐Directed Mutagenesis for the P450 119 Peroxygenase Catalyzed Sulfoxidation of Thioanisole

P450 119 peroxygenase was found to catalyze the sulfoxidation of thioanisole and the sulfonation of sulfoxide in the presence of tert‐butyl hydroperoxide (TBHP) for the first time with turnover rates of 1549 min(−1) and 196 min(−1) respectively. Several mutants were designed to improve the peroxygen...

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Detalles Bibliográficos
Autores principales: Wei, Xiaoyao, Zhang, Chun, Gao, Xiaowei, Gao, Yanping, Yang, Ya, Guo, Kai, Du, Xi, Pu, Lin, Wang, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682931/
https://www.ncbi.nlm.nih.gov/pubmed/31406654
http://dx.doi.org/10.1002/open.201900157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682931/
https://www.ncbi.nlm.nih.gov/pubmed/31406654
http://dx.doi.org/10.1002/open.201900157

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