Structure functional insights into calcium binding during the activation of coagulation factor XIII A

The dimeric FXIII-A(2), a pro-transglutaminase is the catalytic part of the heterotetrameric coagulation FXIII-A(2)B(2) complex that upon activation by calcium binding/thrombin cleavage covalently cross-links preformed fibrin clots protecting them from premature fibrinolysis. Our study characterizes...

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Detalles Bibliográficos
Autores principales: Singh, Sneha, Dodt, Johannes, Volkers, Peter, Hethershaw, Emma, Philippou, Helen, Ivaskevicius, Vytautus, Imhof, Diana, Oldenburg, Johannes, Biswas, Arijit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683118/
https://www.ncbi.nlm.nih.gov/pubmed/31383913
http://dx.doi.org/10.1038/s41598-019-47815-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683118/
https://www.ncbi.nlm.nih.gov/pubmed/31383913
http://dx.doi.org/10.1038/s41598-019-47815-z

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