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Structure functional insights into calcium binding during the activation of coagulation factor XIII A

The dimeric FXIII-A(2), a pro-transglutaminase is the catalytic part of the heterotetrameric coagulation FXIII-A(2)B(2) complex that upon activation by calcium binding/thrombin cleavage covalently cross-links preformed fibrin clots protecting them from premature fibrinolysis. Our study characterizes...

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Detalles Bibliográficos
Autores principales:	Singh, Sneha, Dodt, Johannes, Volkers, Peter, Hethershaw, Emma, Philippou, Helen, Ivaskevicius, Vytautus, Imhof, Diana, Oldenburg, Johannes, Biswas, Arijit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683118/ https://www.ncbi.nlm.nih.gov/pubmed/31383913 http://dx.doi.org/10.1038/s41598-019-47815-z

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