An autophagy-inducing and TLR-2 activating BCG vaccine induces a robust protection against tuberculosis in mice

Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis due to M. tuberculosis (Mtb), which kills millions of people each year. BCG variably protects children, but not adults against tuberculosis. BCG evades phagosome maturation, autophagy, and reduces MHC-II expression of antigen-p...

Descripción completa

Detalles Bibliográficos
Autores principales: Khan, Arshad, Bakhru, Pearl, Saikolappan, Sankaralingam, Das, Kishore, Soudani, Emily, Singh, Christopher R., Estrella, Jaymie L., Zhang, Dekai, Pasare, Chandrashekhar, Ma, Yue, Sun, Jianjun, Wang, Jin, Hunter, Robert L., Tony Eissa, N., Dhandayuthapani, Subramanian, Jagannath, Chinnaswamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683161/
https://www.ncbi.nlm.nih.gov/pubmed/31396406
http://dx.doi.org/10.1038/s41541-019-0122-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683161/
https://www.ncbi.nlm.nih.gov/pubmed/31396406
http://dx.doi.org/10.1038/s41541-019-0122-8

Ejemplares similares