Inhibition of transmembrane TNF-α shedding by a specific antibody protects against septic shock

Transmembrane TNF-α (tmTNF-α) and secretory TNF-α (sTNF-α) display opposite effects in septic shock. Reducing tmTNF-α shedding can offset the detrimental effects of sTNF-α and increase the beneficial effect of tmTNF-α. We previously developed a monoclonal antibody that is specific for tmTNF-α and do...

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Detalles Bibliográficos
Autores principales: Li, Chenxi, Gu, Haiyan, Yu, Mingxia, Yang, Peng, Zhang, Meng, Ba, Hongping, Yin, Yue, Wang, Jing, Yin, Bingjiao, Zhou, Xiaoxi, Li, Zhuoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683172/
https://www.ncbi.nlm.nih.gov/pubmed/31383857
http://dx.doi.org/10.1038/s41419-019-1808-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683172/
https://www.ncbi.nlm.nih.gov/pubmed/31383857
http://dx.doi.org/10.1038/s41419-019-1808-6

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