DPP8/9 inhibitors are universal activators of functional NLRP1 alleles

Intracellular pathogenic structures or activities stimulate the formation of inflammasomes, which recruit and activate caspase-1 and trigger an inflammatory form of cell death called pyroptosis. The well-characterized mammalian inflammasome sensor proteins all detect one specific type of signal, for...

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Detalles Bibliográficos
Autores principales: Gai, Kuo, Okondo, Marian C., Rao, Sahana D., Chui, Ashley J., Ball, Daniel P., Johnson, Darren C., Bachovchin, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683174/
https://www.ncbi.nlm.nih.gov/pubmed/31383852
http://dx.doi.org/10.1038/s41419-019-1817-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683174/
https://www.ncbi.nlm.nih.gov/pubmed/31383852
http://dx.doi.org/10.1038/s41419-019-1817-5

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