A Decoy-Receptor Approach Using Nicotinic Acetylcholine Receptor Mimics Reveals Their Potential as Novel Therapeutics Against Neurotoxic Snakebite

Snakebite is a neglected tropical disease that causes 138,000 deaths each year. Neurotoxic snake venoms contain small neurotoxins, including three-finger toxins (3FTxs), which can cause rapid paralysis in snakebite victims by blocking postsynaptic transmission via nicotinic acetylcholine receptors (...

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Detalles Bibliográficos
Autores principales: Albulescu, Laura-Oana, Kazandjian, Taline, Slagboom, Julien, Bruyneel, Ben, Ainsworth, Stuart, Alsolaiss, Jaffer, Wagstaff, Simon C., Whiteley, Gareth, Harrison, Robert A., Ulens, Chris, Kool, Jeroen, Casewell, Nicholas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683245/
https://www.ncbi.nlm.nih.gov/pubmed/31417406
http://dx.doi.org/10.3389/fphar.2019.00848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683245/
https://www.ncbi.nlm.nih.gov/pubmed/31417406
http://dx.doi.org/10.3389/fphar.2019.00848

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