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Lack of a Synergistic Effect on Cardiometabolic and Redox Markers in a Dietary Supplementation with Anthocyanins and Xanthophylls in Postmenopausal Women

Fruits and vegetables are pivotal for a healthy diet due partly to their content in bioactive compounds. It is for this reason that we conducted a parallel study to unravel the possible effect on cardiometabolic parameters of the ingestion of anthocyanins, xanthophylls, or both groups of bioactives...

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Autores principales: Estévez-Santiago, Rocío, Silván, José Manuel, Can-Cauich, Cesar Abraham, Veses, Ana Maria, Alvarez-Acero, Inma, Martinez-Bartolome, Miguel Angel, San-Román, Ricardo, Cámara, Montaña, Olmedilla-Alonso, Begoña, de Pascual-Teresa, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683247/
https://www.ncbi.nlm.nih.gov/pubmed/31284490
http://dx.doi.org/10.3390/nu11071533
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author Estévez-Santiago, Rocío
Silván, José Manuel
Can-Cauich, Cesar Abraham
Veses, Ana Maria
Alvarez-Acero, Inma
Martinez-Bartolome, Miguel Angel
San-Román, Ricardo
Cámara, Montaña
Olmedilla-Alonso, Begoña
de Pascual-Teresa, Sonia
author_facet Estévez-Santiago, Rocío
Silván, José Manuel
Can-Cauich, Cesar Abraham
Veses, Ana Maria
Alvarez-Acero, Inma
Martinez-Bartolome, Miguel Angel
San-Román, Ricardo
Cámara, Montaña
Olmedilla-Alonso, Begoña
de Pascual-Teresa, Sonia
author_sort Estévez-Santiago, Rocío
collection PubMed
description Fruits and vegetables are pivotal for a healthy diet due partly to their content in bioactive compounds. It is for this reason that we conducted a parallel study to unravel the possible effect on cardiometabolic parameters of the ingestion of anthocyanins, xanthophylls, or both groups of bioactives together in postmenopausal women. Seventy-two postmenopausal women were randomized into an 8-month parallel study: a group consuming 60 mg/day anthocyanins (Group A), a group consuming 6 mg lutein and 2 mg zeaxanthin per day (Group X), and a third group consuming a combination of anthocyanins and xanthophylls in the same amounts (Group A+X). Non-targeted metabolomic analysis was done in plasma samples at baseline and after the 8-month intervention by HPLC-QTOF-MS. Inflammatory, antioxidant, and cardiometabolic parameters were measured at the beginning of the study and after 4 and 8-months intervention. Compared with baseline values, none of the 8-month treatments significantly (p < 0.05) changed systolic or diastolic blood pressure (BP), plasma C-reactive protein, interleukin 6, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, monocyte chemoattractant protein-1 or matrix metalloproteinases 2 and 9. Only plasma glucose levels were significantly decreased by treatment A+X after 8 months, and the plasma metabolomic profile was clearly affected by all three dietary supplementations after 8 months. In parallel, there was an increase, also for the three groups, in the plasma ferric reducing antioxidant power value that did not show any synergistic effect between the two groups of bioactives. Postmenopausal women could benefit from an increase in anthocyanins and xanthophylls intake, through the consumption of fruits and vegetables rich in these two types of compounds. Accordingly, plasma glucose and, above all, the reducing power in plasma, could be improved.
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spelling pubmed-66832472019-08-09 Lack of a Synergistic Effect on Cardiometabolic and Redox Markers in a Dietary Supplementation with Anthocyanins and Xanthophylls in Postmenopausal Women Estévez-Santiago, Rocío Silván, José Manuel Can-Cauich, Cesar Abraham Veses, Ana Maria Alvarez-Acero, Inma Martinez-Bartolome, Miguel Angel San-Román, Ricardo Cámara, Montaña Olmedilla-Alonso, Begoña de Pascual-Teresa, Sonia Nutrients Article Fruits and vegetables are pivotal for a healthy diet due partly to their content in bioactive compounds. It is for this reason that we conducted a parallel study to unravel the possible effect on cardiometabolic parameters of the ingestion of anthocyanins, xanthophylls, or both groups of bioactives together in postmenopausal women. Seventy-two postmenopausal women were randomized into an 8-month parallel study: a group consuming 60 mg/day anthocyanins (Group A), a group consuming 6 mg lutein and 2 mg zeaxanthin per day (Group X), and a third group consuming a combination of anthocyanins and xanthophylls in the same amounts (Group A+X). Non-targeted metabolomic analysis was done in plasma samples at baseline and after the 8-month intervention by HPLC-QTOF-MS. Inflammatory, antioxidant, and cardiometabolic parameters were measured at the beginning of the study and after 4 and 8-months intervention. Compared with baseline values, none of the 8-month treatments significantly (p < 0.05) changed systolic or diastolic blood pressure (BP), plasma C-reactive protein, interleukin 6, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, monocyte chemoattractant protein-1 or matrix metalloproteinases 2 and 9. Only plasma glucose levels were significantly decreased by treatment A+X after 8 months, and the plasma metabolomic profile was clearly affected by all three dietary supplementations after 8 months. In parallel, there was an increase, also for the three groups, in the plasma ferric reducing antioxidant power value that did not show any synergistic effect between the two groups of bioactives. Postmenopausal women could benefit from an increase in anthocyanins and xanthophylls intake, through the consumption of fruits and vegetables rich in these two types of compounds. Accordingly, plasma glucose and, above all, the reducing power in plasma, could be improved. MDPI 2019-07-05 /pmc/articles/PMC6683247/ /pubmed/31284490 http://dx.doi.org/10.3390/nu11071533 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Estévez-Santiago, Rocío
Silván, José Manuel
Can-Cauich, Cesar Abraham
Veses, Ana Maria
Alvarez-Acero, Inma
Martinez-Bartolome, Miguel Angel
San-Román, Ricardo
Cámara, Montaña
Olmedilla-Alonso, Begoña
de Pascual-Teresa, Sonia
Lack of a Synergistic Effect on Cardiometabolic and Redox Markers in a Dietary Supplementation with Anthocyanins and Xanthophylls in Postmenopausal Women
title Lack of a Synergistic Effect on Cardiometabolic and Redox Markers in a Dietary Supplementation with Anthocyanins and Xanthophylls in Postmenopausal Women
title_full Lack of a Synergistic Effect on Cardiometabolic and Redox Markers in a Dietary Supplementation with Anthocyanins and Xanthophylls in Postmenopausal Women
title_fullStr Lack of a Synergistic Effect on Cardiometabolic and Redox Markers in a Dietary Supplementation with Anthocyanins and Xanthophylls in Postmenopausal Women
title_full_unstemmed Lack of a Synergistic Effect on Cardiometabolic and Redox Markers in a Dietary Supplementation with Anthocyanins and Xanthophylls in Postmenopausal Women
title_short Lack of a Synergistic Effect on Cardiometabolic and Redox Markers in a Dietary Supplementation with Anthocyanins and Xanthophylls in Postmenopausal Women
title_sort lack of a synergistic effect on cardiometabolic and redox markers in a dietary supplementation with anthocyanins and xanthophylls in postmenopausal women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683247/
https://www.ncbi.nlm.nih.gov/pubmed/31284490
http://dx.doi.org/10.3390/nu11071533
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