Effects of a Personalized VLCKD on Body Composition and Resting Energy Expenditure in the Reversal of Diabetes to Prevent Complications

The reversion of diabetes and the treatment of long-term obesity are difficult challenges. The failure mechanisms of rapid weight loss are mainly related to the wasting of lean mass. This single-arm study aims to evaluate the effects of a very low-calorie ketogenic diet (VLCKD) on body composition a...

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Autores principales: Romano, Lorenzo, Marchetti, Marco, Gualtieri, Paola, Di Renzo, Laura, Belcastro, Meriann, De Santis, Gemma Lou, Perrone, Marco Alfonso, De Lorenzo, Antonino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683248/
https://www.ncbi.nlm.nih.gov/pubmed/31277506
http://dx.doi.org/10.3390/nu11071526
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author Romano, Lorenzo
Marchetti, Marco
Gualtieri, Paola
Di Renzo, Laura
Belcastro, Meriann
De Santis, Gemma Lou
Perrone, Marco Alfonso
De Lorenzo, Antonino
author_facet Romano, Lorenzo
Marchetti, Marco
Gualtieri, Paola
Di Renzo, Laura
Belcastro, Meriann
De Santis, Gemma Lou
Perrone, Marco Alfonso
De Lorenzo, Antonino
author_sort Romano, Lorenzo
collection PubMed
description The reversion of diabetes and the treatment of long-term obesity are difficult challenges. The failure mechanisms of rapid weight loss are mainly related to the wasting of lean mass. This single-arm study aims to evaluate the effects of a very low-calorie ketogenic diet (VLCKD) on body composition and resting energy expenditure in the short term reversal of diabetes mellitus Type 2. For eight weeks, subjects were administered a personalized VLCKD with protein intake based on lean mass and synthetic amino acidic protein supplementation. Each subject was assessed by anthropometry, Dual-energy X-ray Absorptiometry(DXA), bioimpedentiometric analysis (BIA), indirect calorimetry, and biochemical analysis. The main findings were the saving of lean mass, the reduction of abdominal fat mass, restored metabolic flexibility, the maintenance of resting energy expenditure, and the reversion of diabetes. These results highlight how the application of preventive, predictive, personalized, and participative medicine to nutrition may be promising for the prevention of diabetes and enhancement of obesity treatment.
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spelling pubmed-66832482019-08-09 Effects of a Personalized VLCKD on Body Composition and Resting Energy Expenditure in the Reversal of Diabetes to Prevent Complications Romano, Lorenzo Marchetti, Marco Gualtieri, Paola Di Renzo, Laura Belcastro, Meriann De Santis, Gemma Lou Perrone, Marco Alfonso De Lorenzo, Antonino Nutrients Article The reversion of diabetes and the treatment of long-term obesity are difficult challenges. The failure mechanisms of rapid weight loss are mainly related to the wasting of lean mass. This single-arm study aims to evaluate the effects of a very low-calorie ketogenic diet (VLCKD) on body composition and resting energy expenditure in the short term reversal of diabetes mellitus Type 2. For eight weeks, subjects were administered a personalized VLCKD with protein intake based on lean mass and synthetic amino acidic protein supplementation. Each subject was assessed by anthropometry, Dual-energy X-ray Absorptiometry(DXA), bioimpedentiometric analysis (BIA), indirect calorimetry, and biochemical analysis. The main findings were the saving of lean mass, the reduction of abdominal fat mass, restored metabolic flexibility, the maintenance of resting energy expenditure, and the reversion of diabetes. These results highlight how the application of preventive, predictive, personalized, and participative medicine to nutrition may be promising for the prevention of diabetes and enhancement of obesity treatment. MDPI 2019-07-04 /pmc/articles/PMC6683248/ /pubmed/31277506 http://dx.doi.org/10.3390/nu11071526 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Romano, Lorenzo
Marchetti, Marco
Gualtieri, Paola
Di Renzo, Laura
Belcastro, Meriann
De Santis, Gemma Lou
Perrone, Marco Alfonso
De Lorenzo, Antonino
Effects of a Personalized VLCKD on Body Composition and Resting Energy Expenditure in the Reversal of Diabetes to Prevent Complications
title Effects of a Personalized VLCKD on Body Composition and Resting Energy Expenditure in the Reversal of Diabetes to Prevent Complications
title_full Effects of a Personalized VLCKD on Body Composition and Resting Energy Expenditure in the Reversal of Diabetes to Prevent Complications
title_fullStr Effects of a Personalized VLCKD on Body Composition and Resting Energy Expenditure in the Reversal of Diabetes to Prevent Complications
title_full_unstemmed Effects of a Personalized VLCKD on Body Composition and Resting Energy Expenditure in the Reversal of Diabetes to Prevent Complications
title_short Effects of a Personalized VLCKD on Body Composition and Resting Energy Expenditure in the Reversal of Diabetes to Prevent Complications
title_sort effects of a personalized vlckd on body composition and resting energy expenditure in the reversal of diabetes to prevent complications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683248/
https://www.ncbi.nlm.nih.gov/pubmed/31277506
http://dx.doi.org/10.3390/nu11071526
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