The silencing of indoleamine 2,3-dioxygenase 1 (IDO1) in dendritic cells by siRNA-loaded lipid nanoparticles enhances cell-based cancer immunotherapy

Cell-based therapy using dendritic cells (DC) represents a potent cancer immunotherapy. However, activated DC express indoleamine 2,3-dioxygenase 1 (IDO1), a counter-regulatory and tolerogenic molecule, leading to the inhibition of T cell activation and the promotion of T cell differentiation into r...

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Detalles Bibliográficos
Autores principales: Endo, Rikito, Nakamura, Takashi, Kawakami, Kyoko, Sato, Yusuke, Harashima, Hideyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683295/
https://www.ncbi.nlm.nih.gov/pubmed/31383907
http://dx.doi.org/10.1038/s41598-019-47799-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683295/
https://www.ncbi.nlm.nih.gov/pubmed/31383907
http://dx.doi.org/10.1038/s41598-019-47799-w

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