Magnetic targeting of adoptively transferred tumour-specific nanoparticle-loaded CD8(+) T cells does not improve their tumour infiltration in a mouse model of cancer but promotes the retention of these cells in tumour-draining lymph nodes

BACKGROUND: Adoptive T cell-transfer (ATC) therapy is a highly promising cancer-treatment approach. However, in vivo-administered T cells tend to disperse, with only a small proportion reaching the tumour. To remedy this, magnetic targeting of T cells has been recently explored. Magnetic nanoparticl...

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Detalles Bibliográficos
Autores principales: Sanz-Ortega, Laura, Portilla, Yadileiny, Pérez-Yagüe, Sonia, Barber, Domingo F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683429/
https://www.ncbi.nlm.nih.gov/pubmed/31387604
http://dx.doi.org/10.1186/s12951-019-0520-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683429/
https://www.ncbi.nlm.nih.gov/pubmed/31387604
http://dx.doi.org/10.1186/s12951-019-0520-0

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