SET binding to Sgo1 inhibits Sgo1–cohesin interactions and promotes chromosome segregation

At anaphase onset, Sgo1 function of cohesion protection must be disabled to allow timely chromosome segregation, but how this is achieved is not fully understood. Here, we show that SET, a known PP2A inhibitor, directly binds to a domain in Sgo1 in close proximity to the cohesin-binding motif. The S...

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Detalles Bibliográficos
Autores principales: Qu, Qianhui, Zhang, Qian, Yang, Lu, Chen, Yujue, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683731/
https://www.ncbi.nlm.nih.gov/pubmed/31227592
http://dx.doi.org/10.1083/jcb.201810096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683731/
https://www.ncbi.nlm.nih.gov/pubmed/31227592
http://dx.doi.org/10.1083/jcb.201810096

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