The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes

The generation of protective humoral immunity after vaccination relies on the productive interaction between antigen-specific B cells and T follicular helper (Tfh) cells. Despite the central role of Tfh cells in vaccine responses, there is currently no validated way to enhance their differentiation...

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Detalles Bibliográficos
Autores principales: Hill, Danika L., Pierson, Wim, Bolland, Daniel J., Mkindi, Catherine, Carr, Edward J., Wang, Jiong, Houard, Sophie, Wingett, Steven W., Audran, Regine, Wallin, Elizabeth F., Jongo, Said A., Kamaka, Kassim, Zand, Martin, Spertini, Francois, Daubenberger, Claudia, Corcoran, Anne E., Linterman, Michelle A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683991/
https://www.ncbi.nlm.nih.gov/pubmed/31175140
http://dx.doi.org/10.1084/jem.20190301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683991/
https://www.ncbi.nlm.nih.gov/pubmed/31175140
http://dx.doi.org/10.1084/jem.20190301

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