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Knockout of longevity gene Sirt1 in zebrafish leads to oxidative injury, chronic inflammation, and reduced life span

Sirt1, a member of the sirtuin gene family, encodes the most conserved mammalian NAD(+)-dependent deacetylase enzyme responsible for removing acetyl groups from many proteins. The Sirt1 gene is known as a longevity gene whose knockout in mice leads to decreased lifespan relative to the wild type. Th...

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Detalles Bibliográficos
Autores principales: Kim, Do Hee, Jung, In Hye, Kim, Dong Hee, Park, Seung Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684063/
https://www.ncbi.nlm.nih.gov/pubmed/31386694
http://dx.doi.org/10.1371/journal.pone.0220581