Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity

Reduced mRNA translation delays aging, but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6 kinase/S6K) cause synergistic lifespan extension in C. elegans. To understand the roles of translational regulation in this process, we perform...

Descripción completa

Detalles Bibliográficos
Autores principales: Lan, Jianfeng, Rollins, Jarod A., Zang, Xiao, Wu, Di, Zou, Lina, Wang, Zi, Ye, Chang, Wu, Zixing, Kapahi, Pankaj, Rogers, Aric N., Chen, Di
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684276/
https://www.ncbi.nlm.nih.gov/pubmed/31340143
http://dx.doi.org/10.1016/j.celrep.2019.06.078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684276/
https://www.ncbi.nlm.nih.gov/pubmed/31340143
http://dx.doi.org/10.1016/j.celrep.2019.06.078

Ejemplares similares