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CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation
CD40 has major roles in B cell development, activation, and germinal center responses. CD40 hypoactivity causes immunodeficiency whereas its overexpression causes autoimmunity and lymphomagenesis. To systematically identify B cell autonomous CD40 regulators, we use CRISPR/Cas9 genome-scale screens i...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684324/ https://www.ncbi.nlm.nih.gov/pubmed/31365872 http://dx.doi.org/10.1016/j.celrep.2019.06.079 |