CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation

CD40 has major roles in B cell development, activation, and germinal center responses. CD40 hypoactivity causes immunodeficiency whereas its overexpression causes autoimmunity and lymphomagenesis. To systematically identify B cell autonomous CD40 regulators, we use CRISPR/Cas9 genome-scale screens i...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Chang, Trudeau, Stephen J., Cheong, Taek-Chin, Guo, Rui, Teng, Mingxiang, Wang, Liang Wei, Wang, Zhonghao, Pighi, Chiara, Gautier-Courteille, Carole, Ma, Yijie, Jiang, Sizun, Wang, Chong, Zhao, Bo, Paillard, Luc, Doench, John G., Chiarle, Roberto, Gewurz, Benjamin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684324/
https://www.ncbi.nlm.nih.gov/pubmed/31365872
http://dx.doi.org/10.1016/j.celrep.2019.06.079

Ejemplares similares

Ejemplares similares