Damage sensor role of UV-DDB during base excision repair

UV-DDB, a key protein in human global nucleotide excision repair (NER), binds avidly to abasic sites and 8-oxo-guanine (8-oxoG), suggesting a non-canonical role in base excision repair (BER). We investigated whether UV-DDB can stimulate BER for these two common forms of DNA damage, 8-oxoG and abasic...

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Detalles Bibliográficos
Autores principales: Jang, Sunbok, Kumar, Namrata, Beckwitt, Emily C., Kong, Muwen, Fouquerel, Elise, Rapić-Otrin, Vesna, Prasad, Rajendra, Watkins, Simon C., Khuu, Cindy, Majumdar, Chandrima, David, Sheila S., Wilson, Samuel H., Bruchez, Marcel P., Opresko, Patricia L., Van Houten, Bennett
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684372/
https://www.ncbi.nlm.nih.gov/pubmed/31332353
http://dx.doi.org/10.1038/s41594-019-0261-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684372/
https://www.ncbi.nlm.nih.gov/pubmed/31332353
http://dx.doi.org/10.1038/s41594-019-0261-7

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