Follistatin-based ligand trap ACE-083 induces localized hypertrophy of skeletal muscle with functional improvement in models of neuromuscular disease

Skeletal muscle is under inhibitory homeostatic regulation by multiple ligands of the transforming growth factor-β (TGFβ) superfamily. Follistatin is a secreted protein that promotes muscle growth and function by sequestering these ligands extracellularly. In the present study, we evaluated the pote...

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Detalles Bibliográficos
Autores principales: Pearsall, R. S., Davies, M. V., Cannell, M., Li, J., Widrick, J., Mulivor, A. W., Wallner, S., Troy, M. E., Spaits, M., Liharska, K., Sako, D., Castonguay, R., Keates, S., Grinberg, A. V., Suragani, R. N. V. S., Kumar, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684588/
https://www.ncbi.nlm.nih.gov/pubmed/31388039
http://dx.doi.org/10.1038/s41598-019-47818-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684588/
https://www.ncbi.nlm.nih.gov/pubmed/31388039
http://dx.doi.org/10.1038/s41598-019-47818-w

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