Structural basis for the target specificity of actin histidine methyltransferase SETD3

SETD3 is an actin histidine-N(3) methyltransferase, whereas other characterized SET-domain enzymes are protein lysine methyltransferases. We report that in a pre-reactive complex SETD3 binds the N(3)-protonated form (N(3)-H) of actin His73, and in a post-reactive product complex, SETD3 generates the...

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Detalles Bibliográficos
Autores principales: Dai, Shaobo, Horton, John R., Woodcock, Clayton B., Wilkinson, Alex W., Zhang, Xing, Gozani, Or, Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684798/
https://www.ncbi.nlm.nih.gov/pubmed/31388018
http://dx.doi.org/10.1038/s41467-019-11554-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684798/
https://www.ncbi.nlm.nih.gov/pubmed/31388018
http://dx.doi.org/10.1038/s41467-019-11554-6

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