Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective

The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses ligand-independent basal signaling activity (...

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Detalles Bibliográficos
Autores principales: Heyder, Nicolas, Kleinau, Gunnar, Szczepek, Michal, Kwiatkowski, Dennis, Speck, David, Soletto, Lucia, Cerdá-Reverter, José Miguel, Krude, Heiko, Kühnen, Peter, Biebermann, Heike, Scheerer, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685040/
https://www.ncbi.nlm.nih.gov/pubmed/31417496
http://dx.doi.org/10.3389/fendo.2019.00515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685040/
https://www.ncbi.nlm.nih.gov/pubmed/31417496
http://dx.doi.org/10.3389/fendo.2019.00515

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