Squaramide‐Based 5’‐Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A

Phosphate groups are often crucial to biological activity and interactions of oligonucleotides, but confer poor membrane permeability. In addition, the group's lability to enzymatic hydrolysis is an obstacle to its use in therapeutics and in biological tools. We present the synthesis of N‐oxyam...

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Detalles Bibliográficos
Autores principales: Dürr, Eva‐Maria, Doherty, William, Lee, Sook Y., El‐Sagheer, Afaf H., Shivalingam, Arun, McHugh, Peter J., Brown, Tom, McGouran, Joanna F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685075/
https://www.ncbi.nlm.nih.gov/pubmed/31414040
http://dx.doi.org/10.1002/slct.201803375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685075/
https://www.ncbi.nlm.nih.gov/pubmed/31414040
http://dx.doi.org/10.1002/slct.201803375

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