Cargando…

Identification of novel antifungal agents: antimicrobial evaluation, SAR, ADME–Tox and molecular docking studies of a series of imidazole derivatives

Thirty-four imidazole-based compounds synthesized by one-pot catalytic method were evaluated for their antifungal and antibacterial activities against several fungal and bacterial strains. None of the compounds had antibacterial activity. Interestingly, compounds 1, 2, 3, 10 and 15 displayed a stron...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bouchal, Btissam, Abrigach, Farid, Takfaoui, Abdelilah, Elidrissi Errahhali, Manal, Elidrissi Errahhali, Mounia, Dixneuf, Pierre H., Doucet, Henri, Touzani, Rachid, Bellaoui, Mohammed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685181/ https://www.ncbi.nlm.nih.gov/pubmed/31410411 http://dx.doi.org/10.1186/s13065-019-0623-6

Ejemplares similares

Correction: Exploring Geographic Variability in Cancer Prevalence in Eastern Morocco: a Retrospective Study over Eight Years
por: Errahhali, Manal Elidrissi, et al.
Publicado: (2016)

Exploring Geographic Variability in Cancer Prevalence in Eastern Morocco: A Retrospective Study over Eight Years
por: Elidrissi Errahhali, Manal, et al.
Publicado: (2016)

Distribution and features of hematological malignancies in Eastern Morocco: a retrospective multicenter study over 5 years
por: Elidrissi Errahhali, Mounia, et al.
Publicado: (2016)

Cancer incidence in eastern Morocco: cancer patterns and incidence trends, 2005–2012
por: Elidrissi Errahhali, Manal, et al.
Publicado: (2017)

First report on molecular breast cancer subtypes and their clinico-pathological characteristics in Eastern Morocco: series of 2260 cases
por: Elidrissi Errahhali, Manal, et al.
Publicado: (2017)

Molecular heterogeneity of β‐thalassemia variants in the Eastern region of Morocco
por: Belmokhtar, Ihab, et al.
Publicado: (2022)

Double Isochromosome X, a Rare Cytogenetic Variant of Turner Syndrome: A Case Report and a Review of the Literature
por: Zerrouki, K., et al.
Publicado: (2023)

New N-Alkylated Heterocyclic Compounds as Prospective NDM1 Inhibitors: Investigation of In Vitro and In Silico Properties
por: Kaddouri, Yassine, et al.
Publicado: (2022)

Pyrazole, imidazole and triazole: In silico, docking and ADMET studies against SARS-CoV-2
por: Mohamed, Mounir, et al.
Publicado: (2023)

New thiazole, pyridine and pyrazole derivatives as antioxidant candidates: synthesis, DFT calculations and molecular docking study
por: Kaddouri, Yassine, et al.
Publicado: (2020)

Morocco's First Biobank: Establishment, Ethical Issues, Biomedical Research Opportunities, and Challenges
por: Lhousni, Saida, et al.
Publicado: (2020)

3D-QSAR, ADME-Tox, and molecular docking of semisynthetic triterpene derivatives as antibacterial and insecticide agents
por: Daoui, Ossama, et al.
Publicado: (2022)

Molecular Docking and ADME-TOX Profiling of Moringa oleifera Constituents against SARS-CoV-2
por: Souza, Hellen Cris Araújo, et al.
Publicado: (2023)

The use of quantum chemistry in the prediction of ADME-Tox properties
por: Van Damme, S, et al.
Publicado: (2008)

In Vitro, Molecular Docking and In Silico ADME/Tox Studies of Emodin and Chrysophanol against Human Colorectal and Cervical Carcinoma
por: Ahmad, Wasim, et al.
Publicado: (2022)

FAF-Drugs: free ADME/tox filtering of compound collections
por: Miteva, Maria A., et al.
Publicado: (2006)

3D-QSAR, Docking, ADME/Tox studies on Flavone analogs reveal anticancer activity through Tankyrase inhibition
por: Alam, Sarfaraz, et al.
Publicado: (2019)

Molecular docking studies and ADME-Tox prediction of phytocompounds from Merremia peltata as a potential anti-alopecia treatment
por: Abdurrahman, Syawal, et al.
Publicado: (2021)

In Silico ADME/Tox Profiling of Natural Products: A Focus on BIOFACQUIM
por: Durán-Iturbide, Noemi Angeles, et al.
Publicado: (2020)

Applications of the microphysiology systems database for experimental ADME-Tox and disease models
por: Schurdak, Mark, et al.
Publicado: (2020)

Comparison of Descriptor- and Fingerprint Sets in Machine Learning Models for ADME-Tox Targets
por: Orosz, Álmos, et al.
Publicado: (2022)

Computational investigation of unsaturated ketone derivatives as MAO-B inhibitors by using QSAR, ADME/Tox, molecular docking, and molecular dynamics simulations
por: EL AISSOUQ, Abdellah, et al.
Publicado: (2021)

Mono-Alkylated Ligands Based on Pyrazole and Triazole Derivatives Tested Against Fusarium oxysporum f. sp. albedinis: Synthesis, Characterization, DFT, and Phytase Binding Site Identification Using Blind Docking/Virtual Screening for Potent Fophy Inhibitors
por: Kaddouri, Yassine, et al.
Publicado: (2020)

Dipeptidyl peptidase IV inhibition of phytocompounds from Artocarpus champeden (Lour.) Stokes: In silico molecular docking study and ADME-Tox prediction approach
por: Supandi, Supandi, et al.
Publicado: (2022)

QSAR, ADME-Tox, molecular docking and molecular dynamics simulations of novel selective glycine transporter type 1 inhibitors with memory enhancing properties
por: El fadili, Mohamed, et al.
Publicado: (2023)

Open Source Bayesian Models. 1. Application to ADME/Tox and Drug Discovery Datasets
por: Clark, Alex M., et al.
Publicado: (2015)

Potential Therapeutic Approaches to Alzheimer’s Disease By Bioinformatics, Cheminformatics And Predicted Adme-Tox Tools
por: Avram, Speranta, et al.
Publicado: (2020)

Prediction of ADME-Tox properties and toxicological endpoints of triazole fungicides used for cereals protection
por: Gridan, Ionuţ Mădălin, et al.
Publicado: (2019)

Synthesis of indole-based oxadiazoles and their interaction with bacterial peptidoglycan and SARS-CoV-2 main protease: In vitro, molecular docking and in silico ADME/Tox study
por: Ansari, Mohammad Azam, et al.
Publicado: (2022)

FAF-Drugs2: Free ADME/tox filtering tool to assist drug discovery and chemical biology projects
por: Lagorce, David, et al.
Publicado: (2008)

Bioprinted 3D Primary Human Intestinal Tissues Model Aspects of Native Physiology and ADME/Tox Functions
por: Madden, Lauran R., et al.
Publicado: (2018)

In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases
por: Więckowska, Anna, et al.
Publicado: (2020)

Molecular docking studies, molecular dynamics and ADME/tox reveal therapeutic potentials of STOCK1N-69160 against papain-like protease of SARS-CoV-2
por: Elekofehinti, Olusola Olalekan, et al.
Publicado: (2020)

Virtual screening, ADME/Tox predictions and the drug repurposing concept for future use of old drugs against the COVID-19
por: Hage-Melim, Lorane Izabel da Silva, et al.
Publicado: (2020)

Greenness assessment of UPLC/MS/MS method for determination of two antihypertensive agents and their harmful impurities with ADME/TOX profile study
por: Nagieb, Hend M., et al.
Publicado: (2023)

Synthesis, molecular docking, and in silico ADME/Tox profiling studies of new 1-aryl-5-(3-azidopropyl)indol-4-ones: Potential inhibitors of SARS CoV-2 main protease
por: Domínguez-Villa, Francisco Xavier, et al.
Publicado: (2021)

Bioinformatics analysis of adhesin-binding potential and ADME/Tox profile of anti-Helicobacter pylori peptides derived from wheat germ proteins()
por: Dang, Chi, et al.
Publicado: (2022)

Geant adrenal myelolipoma: A case report with literature review
por: Rkik, Mustapha, et al.
Publicado: (2020)

Giant hydronephrosis secondary to ureteral calculi in adults: Case report and literature review
por: Rkik, Mustapha, et al.
Publicado: (2021)

A rare entity of bilateral hutch diverticulum asymptomatic in adult revealed during the assessment of hematuria
por: Rkik, Mustapha, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0i2acu9n23l264ft53a7a7rdke