Identification of potential binding pocket on viral oncoprotein HPV16 E6: a promising anti-cancer target for small molecule drug discovery

BACKGROUND: Several human cancers, especially cervical cancer are caused by the infection of high risk strains of human papillomaviruses (HPV), notably HPV16. It is implicated that the oncoprotein E6 expressed from HPV, is inhibiting the apoptotic pathway by binding to adaptor molecule FADD (Fas-ass...

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Detalles Bibliográficos
Autores principales: Kolluru, Srikanth, Momoh, Rosemary, Lin, Lydia, Mallareddy, Jayapal Reddy, Krstenansky, John L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685234/
https://www.ncbi.nlm.nih.gov/pubmed/31387520
http://dx.doi.org/10.1186/s12860-019-0214-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685234/
https://www.ncbi.nlm.nih.gov/pubmed/31387520
http://dx.doi.org/10.1186/s12860-019-0214-3

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