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Genetic Variation in Human Gene Regulatory Factors Uncovers Regulatory Roles in Local Adaptation and Disease

Differences in gene regulation have been suggested to play essential roles in the evolution of phenotypic changes. Although DNA changes in cis-regulatory elements affect only the regulation of its corresponding gene, variations in gene regulatory factors (trans) can have a broader effect, because th...

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Detalles Bibliográficos
Autores principales: Perdomo-Sabogal, Álvaro, Nowick, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685493/
https://www.ncbi.nlm.nih.gov/pubmed/31228201
http://dx.doi.org/10.1093/gbe/evz131