Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27(Kip1) signaling axis

In tissues, cells reside in confining microenvironments, which may mechanically restrict the ability of a cell to double in size as it prepares to divide. How confinement affects cell cycle progression remains unclear. We show that cells progressed through the cell cycle and proliferated when cultur...

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Detalles Bibliográficos
Autores principales: Nam, Sungmin, Gupta, Vivek Kumar, Lee, Hong-pyo, Lee, Joanna Y., Wisdom, Katrina M., Varma, Sushama, Flaum, Eliott Marie, Davis, Ciara, West, Robert B., Chaudhuri, Ovijit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685709/
https://www.ncbi.nlm.nih.gov/pubmed/31457089
http://dx.doi.org/10.1126/sciadv.aaw6171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685709/
https://www.ncbi.nlm.nih.gov/pubmed/31457089
http://dx.doi.org/10.1126/sciadv.aaw6171

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