Plumbagin-induced oxidative stress leads to inhibition of Na(+)/K(+)-ATPase (NKA) in canine cancer cells

The Na(+)/K(+)-ATPase (NKA) complex is the master regulator of membrane potential and a target for anti-cancer therapies. Here, we investigate the effect of drug-induced oxidative stress on NKA activity. The natural product, plumbagin increases oxygen radicals through inhibition of oxidative phospho...

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Detalles Bibliográficos
Autores principales: Alharbi, Yousef, Kapur, Arvinder, Felder, Mildred, Barroilhet, Lisa, Stein, Timothy, Pattnaik, Bikash R., Patankar, Manish S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685937/
https://www.ncbi.nlm.nih.gov/pubmed/31391478
http://dx.doi.org/10.1038/s41598-019-47261-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685937/
https://www.ncbi.nlm.nih.gov/pubmed/31391478
http://dx.doi.org/10.1038/s41598-019-47261-x

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