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Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis
Methods for the late-stage diversification of structurally complex peptides hold enormous potential for advances in drug discovery, agrochemistry and pharmaceutical industries. While C–H arylations emerged for peptide modifications, they are largely limited to highly reactive, expensive and/or toxic...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685959/ https://www.ncbi.nlm.nih.gov/pubmed/31391461 http://dx.doi.org/10.1038/s41467-019-11395-3 |