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Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis

Methods for the late-stage diversification of structurally complex peptides hold enormous potential for advances in drug discovery, agrochemistry and pharmaceutical industries. While C–H arylations emerged for peptide modifications, they are largely limited to highly reactive, expensive and/or toxic...

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Detalles Bibliográficos
Autores principales: Schischko, Alexandra, Kaplaneris, Nikolaos, Rogge, Torben, Sirvinskaite, Giedre, Son, Jongwoo, Ackermann, Lutz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685959/
https://www.ncbi.nlm.nih.gov/pubmed/31391461
http://dx.doi.org/10.1038/s41467-019-11395-3

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