Cargando…
Autophagy inhibition-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF), the prototypic progressive fibrotic interstitial lung disease, is thought to be a consequence of repetitive micro-injuries to an ageing, susceptible alveolar epithelium. Ageing is a risk factor for IPF and incidence has been demonstrated to increase with age. Dec...
Autores principales: | Hill, Charlotte, Li, Juanjuan, Liu, Dian, Conforti, Franco, Brereton, Christopher J., Yao, Liudi, Zhou, Yilu, Alzetani, Aiman, Chee, Serena J., Marshall, Ben G., Fletcher, Sophie V., Hancock, David, Ottensmeier, Christian H., Steele, Andrew J., Downward, Julian, Richeldi, Luca, Lu, Xin, Davies, Donna E., Jones, Mark G., Wang, Yihua |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685977/ https://www.ncbi.nlm.nih.gov/pubmed/31391462 http://dx.doi.org/10.1038/s41419-019-1820-x |
Ejemplares similares
-
Paracrine signalling during ZEB1-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in lung fibrosis
por: Yao, Liudi, et al.
Publicado: (2018) -
Bidirectional epithelial–mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis
por: Yao, Liudi, et al.
Publicado: (2021) -
Paracrine SPARC signaling dysregulates alveolar epithelial barrier integrity and function in lung fibrosis
por: Conforti, Franco, et al.
Publicado: (2020) -
Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial–Mesenchymal Transition
por: Zhou, Yilu, et al.
Publicado: (2021) -
Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
por: Brereton, Christopher J, et al.
Publicado: (2022)