Blockade of miR-140-3p prevents functional deterioration in afterload-enhanced engineered heart tissue

Afterload enhancement (AE) of rat engineered heart tissue (EHT) in vitro leads to a multitude of changes that in vivo are referred to as pathological cardiac hypertrophy: e.g., cardiomyocyte hypertrophy, contractile dysfunction, reactivation of fetal genes and fibrotic changes. Moreover AE induced t...

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Detalles Bibliográficos
Autores principales: Werner, Tessa R., Kunze, Ann-Cathrin, Stenzig, Justus, Eschenhagen, Thomas, Hirt, Marc N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686025/
https://www.ncbi.nlm.nih.gov/pubmed/31391475
http://dx.doi.org/10.1038/s41598-019-46818-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686025/
https://www.ncbi.nlm.nih.gov/pubmed/31391475
http://dx.doi.org/10.1038/s41598-019-46818-0

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