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Sleeping Beauty Transposon-Mediated Asparaginase Gene Delivery by a Nanoparticle Platform
Transgenic genome integration using non-viral vehicles is a promising approach for gene therapy. Previous studies reported that asparagine is a key regulator of cancer cell amino acid homeostasis, anabolic metabolism and cell proliferation. The depletion of asparagine would inhibit the growth of man...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686048/ https://www.ncbi.nlm.nih.gov/pubmed/31391525 http://dx.doi.org/10.1038/s41598-019-47927-6 |