Cargando…

CD4(+) T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis B

BACKGROUND: Immune inhibitory receptors play an important role in chronic infections. However, little is known about their role in hepatitis B virus (HBV) infection. Here, we analyzed the relationship between programmed death-1 (PD-1) and lymphocyte activation gene-3 (LAG-3) expression on CD4(+) T c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Yuejiao, Li, Xuefen, Zhang, Lu, Zhu, Qiaoyun, Chen, Chunlei, Bao, Jiaqi, Chen, Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686459/ https://www.ncbi.nlm.nih.gov/pubmed/31390978 http://dx.doi.org/10.1186/s12865-019-0309-9

Ejemplares similares

Changes of Costimulatory Molecule CD28 on Circulating CD8(+) T Cells Correlate with Disease Pathogenesis of Chronic Hepatitis B
por: Li, Xuefen, et al.
Publicado: (2014)

PD-1 blockade restores helper activity of tumor-infiltrating, exhausted PD-1(hi)CD39(+) CD4 T cells
por: Balança, Camille-Charlotte, et al.
Publicado: (2021)

Cooperation of PD-1 and LAG-3 in the exhaustion of CD4(+) and CD8(+) T cells during bovine leukemia virus infection
por: Okagawa, Tomohiro, et al.
Publicado: (2018)

Circulating Exhausted PD-1(+)CD39(+) Helper CD4 T Cells Are Tumor-Antigen-Specific and Predict Response to PD-1/PD-L1 Axis Blockade
por: Martinez-Gomez, Carlos, et al.
Publicado: (2022)

Increasing LAG-3 expression suppresses T-cell function in chronic hepatitis B: A balance between immunity strength and liver injury extent
por: Ye, Bo, et al.
Publicado: (2017)

Autoreactive CD8(+) T cells are restrained by an exhaustion-like program that is maintained by LAG3
por: Grebinoski, Stephanie, et al.
Publicado: (2022)

Expression of LAG-3 defines exhaustion of intratumoral PD-1(+) T cells and correlates with poor outcome in follicular lymphoma
por: Yang, Zhi-Zhang, et al.
Publicado: (2017)

Squamous cell carcinomas escape immune surveillance via inducing chronic activation and exhaustion of CD8(+) T Cells co-expressing PD-1 and LAG-3 inhibitory receptors
por: Mishra, Ameet K., et al.
Publicado: (2016)

Dynamic Network Biomarker of Pre-Exhausted CD8(+) T Cells Contributed to T Cell Exhaustion in Colorectal Cancer
por: Hu, Jiaqi, et al.
Publicado: (2021)

Kidney Failure Associates With T Cell Exhaustion and Imbalanced Follicular Helper T Cells
por: Hartzell, Susan, et al.
Publicado: (2020)

Blockade of PD-1 and LAG-3 expression on CD8+ T cells promotes the tumoricidal effects of CD8+ T cells
por: Ma, Jiajia, et al.
Publicado: (2023)

CXCR5(+)PD-1(+) follicular helper CD8 T cells control B cell tolerance
por: Chen, Yuhong, et al.
Publicado: (2019)

Different Expression Characteristics of LAG3 and PD-1 in Sepsis and Their Synergistic Effect on T Cell Exhaustion: A New Strategy for Immune Checkpoint Blockade
por: Niu, Bailin, et al.
Publicado: (2019)

Mathematical modeling identifies LAG3 and HAVCR2 as biomarkers of T cell exhaustion in melanoma
por: Beck, Richard J., et al.
Publicado: (2023)

CD40 Activation Rescues Antiviral CD8(+) T Cells from PD-1-Mediated Exhaustion
por: Isogawa, Masanori, et al.
Publicado: (2013)

LAG3 and PD1 Regulate CD8+ T Cell in Diffuse Large B-cell Lymphoma Patients
por: Liu, Ying, et al.
Publicado: (2021)

PD-1 and BTLA and CD8(+) T-cell “exhaustion” in cancer: “Exercising” an alternative viewpoint
por: Haymaker, Cara, et al.
Publicado: (2012)

Downregulated IL-21 Response and T Follicular Helper Cell Exhaustion Correlate with Compromised CD8 T Cell Immunity during Chronic Toxoplasmosis
por: Moretto, Magali M., et al.
Publicado: (2017)

Correction: CD40 Activation Rescues Antiviral CD8(+) T Cells from PD-1-Mediated Exhaustion
por: Isogawa, Masanori, et al.
Publicado: (2016)

Correction: CD40 Activation Rescues Antiviral CD8(+) T Cells from PD-1-Mediated Exhaustion
por: Isogawa, Masanori, et al.
Publicado: (2017)

Retracted: LAG3 and PD1 Regulate CD8+ T Cell in Diffuse Large B-cell Lymphoma Patients
por: Methods in Medicine, Computational and Mathematical
Publicado: (2023)

Exhausted phenotype of circulating CD8(+) T cell subsets in hepatitis B virus carriers
por: Jiang, Daixi, et al.
Publicado: (2022)

Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8(+) T cells
por: Odorizzi, Pamela M., et al.
Publicado: (2015)

CD4(+) T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART
por: Fromentin, Rémi, et al.
Publicado: (2016)

Follicular helper T cell signature of replicative exhaustion, apoptosis, and senescence in common variable immunodeficiency
por: Milardi, Giulia, et al.
Publicado: (2022)

Follicular helper-T cells restore CD8(+)-dependent antitumor immunity and anti-PD-L1/PD-1 efficacy
por: Niogret, Julie, et al.
Publicado: (2021)

Higher Frequency of CD4(+)CXCR5(+)ICOS(+)PD1(+) T Follicular Helper Cells in Patients With Infectious Mononucleosis
por: Liu, Jinlin, et al.
Publicado: (2015)

PD1(Hi) CD8(+) T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma
por: Ma, Jiaqiang, et al.
Publicado: (2019)

JNK/c‐Jun pathway activation is essential for HBx‐induced IL‐35 elevation to promote persistent HBV infection
por: Li, Xuefen, et al.
Publicado: (2023)

CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1(+) viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion
por: Correa-Rocha, Rafael, et al.
Publicado: (2018)

Impact of CD4 T cells on intratumoral CD8 T-cell exhaustion and responsiveness to PD-1 blockade therapy in mouse brain tumors
por: Khan, Saad M, et al.
Publicado: (2022)

CD8(+) T Cell Exhaustion in Cancer
por: Dolina, Joseph S., et al.
Publicado: (2021)

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion
por: Peng, David H., et al.
Publicado: (2020)

Loss of CD28 expression associates with severe T-cell exhaustion in acute myeloid leukemia
por: Huang, Yueting, et al.
Publicado: (2023)

CD26(low)PD-1(+) CD8 T cells are terminally exhausted and associated with leukemia progression in acute myeloid leukemia
por: Zhou, Huarong, et al.
Publicado: (2023)

Breast Cancer Cells and PD-1/PD-L1 Blockade Upregulate the Expression of PD-1, CTLA-4, TIM-3 and LAG-3 Immune Checkpoints in CD4(+) T Cells
por: Saleh, Reem, et al.
Publicado: (2019)

Correction: Impact of CD4 T cells on intratumoral CD8 T-cell exhaustion and responsiveness to PD-1 blockade therapy in mouse brain tumors
Publicado: (2023)

Loss of Circulating CD4 T Cells with B Cell Helper Function during Chronic HIV Infection
por: Boswell, Kristin L., et al.
Publicado: (2014)

Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells
por: Lichtenegger, Felix S., et al.
Publicado: (2018)

PD-1 Controls Follicular T Helper Cell Positioning and Function
por: Shi, Jingwen, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_29k58mqo809n8tckuc68ltdqbe