Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications

Antisense oligonucleotides (ASOs) are becoming important drugs for hard to treat diseases. Modifications to their DNA backbones are essential to inhibit degradation in vivo, but they can reduce binding affinity to RNA targets. To address this problem we have combined the enzymatic resistance of carb...

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Detalles Bibliográficos
Autores principales: Thorpe, Cameron, Epple, Sven, Woods, Benjamin, El-Sagheer, Afaf H., Brown, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686644/
https://www.ncbi.nlm.nih.gov/pubmed/31099373
http://dx.doi.org/10.1039/c9ob00691e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686644/
https://www.ncbi.nlm.nih.gov/pubmed/31099373
http://dx.doi.org/10.1039/c9ob00691e

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