Effect of Sugar 2′,4′-Modifications on Gene Silencing Activity of siRNA Duplexes

In this study, we explore the effect of a library of 2′-, 4′-, and 2′,4′-modified uridine nucleosides and their impact on silencing firefly luciferase and on down-regulated in renal cell carcinoma (DRR) gene targets. The modifications studied were 2′-F-ribose, 2′-F-arabinose, 2′-OMe-ribose, 2′-F,4′-...

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Detalles Bibliográficos
Autores principales: Malek-Adamian, Elise, Fakhoury, Johans, Arnold, Amy E., Martínez-Montero, Saúl, Shoichet, Molly S., Damha, Masad J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686699/
https://www.ncbi.nlm.nih.gov/pubmed/31084536
http://dx.doi.org/10.1089/nat.2019.0792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686699/
https://www.ncbi.nlm.nih.gov/pubmed/31084536
http://dx.doi.org/10.1089/nat.2019.0792

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