CRISPR screens are feasible in TP53 wild‐type cells

A recent study by Haapaniemi et al (2018) reported that intact p53 signaling hampers CRISPR‐based functional genomic screens. Brown et al report good performance of genome‐scale screens in TP53 wild‐type cells and reiterate best practices for CRISPR screening. [Image: see text]

Detalles Bibliográficos
Autores principales: Brown, Kevin R, Mair, Barbara, Soste, Martin, Moffat, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686785/
https://www.ncbi.nlm.nih.gov/pubmed/31464370
http://dx.doi.org/10.15252/msb.20188679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686785/
https://www.ncbi.nlm.nih.gov/pubmed/31464370
http://dx.doi.org/10.15252/msb.20188679

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