CRISPR screens are feasible in TP53 wild‐type cells

A recent study by Haapaniemi et al (2018) reported that intact p53 signaling hampers CRISPR‐based functional genomic screens. Brown et al report good performance of genome‐scale screens in TP53 wild‐type cells and reiterate best practices for CRISPR screening. [Image: see text]

Detalles Bibliográficos
Autores principales: Brown, Kevin R, Mair, Barbara, Soste, Martin, Moffat, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686785/
https://www.ncbi.nlm.nih.gov/pubmed/31464370
http://dx.doi.org/10.15252/msb.20188679
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author Brown, Kevin R
Mair, Barbara
Soste, Martin
Moffat, Jason
author_facet Brown, Kevin R
Mair, Barbara
Soste, Martin
Moffat, Jason
author_sort Brown, Kevin R
collection PubMed
description A recent study by Haapaniemi et al (2018) reported that intact p53 signaling hampers CRISPR‐based functional genomic screens. Brown et al report good performance of genome‐scale screens in TP53 wild‐type cells and reiterate best practices for CRISPR screening. [Image: see text]
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spelling pubmed-66867852019-08-13 CRISPR screens are feasible in TP53 wild‐type cells Brown, Kevin R Mair, Barbara Soste, Martin Moffat, Jason Mol Syst Biol Correspondence A recent study by Haapaniemi et al (2018) reported that intact p53 signaling hampers CRISPR‐based functional genomic screens. Brown et al report good performance of genome‐scale screens in TP53 wild‐type cells and reiterate best practices for CRISPR screening. [Image: see text] John Wiley and Sons Inc. 2019-08-08 /pmc/articles/PMC6686785/ /pubmed/31464370 http://dx.doi.org/10.15252/msb.20188679 Text en © 2019 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Correspondence
Brown, Kevin R
Mair, Barbara
Soste, Martin
Moffat, Jason
CRISPR screens are feasible in TP53 wild‐type cells
title CRISPR screens are feasible in TP53 wild‐type cells
title_full CRISPR screens are feasible in TP53 wild‐type cells
title_fullStr CRISPR screens are feasible in TP53 wild‐type cells
title_full_unstemmed CRISPR screens are feasible in TP53 wild‐type cells
title_short CRISPR screens are feasible in TP53 wild‐type cells
title_sort crispr screens are feasible in tp53 wild‐type cells
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686785/
https://www.ncbi.nlm.nih.gov/pubmed/31464370
http://dx.doi.org/10.15252/msb.20188679
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AT mairbarbara crisprscreensarefeasibleintp53wildtypecells
AT sostemartin crisprscreensarefeasibleintp53wildtypecells
AT moffatjason crisprscreensarefeasibleintp53wildtypecells

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