40 Years of Change in Age- and Stage-Specific Cancer Incidence Rates in US Women and Men

BACKGROUND: Studies have documented a temporal increase in incidence for several cancers in US young adults aged 25 to 39-years, including noncardia gastric cancer, colorectal cancer, and distant-stage breast cancer. To further characterize trends in young adults, we assessed age-specific and stage-...

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Autores principales: Kehm, Rebecca D, Yang, Wan, Tehranifar, Parisa, Terry, Mary Beth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686848/
https://www.ncbi.nlm.nih.gov/pubmed/31414075
http://dx.doi.org/10.1093/jncics/pkz038
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author Kehm, Rebecca D
Yang, Wan
Tehranifar, Parisa
Terry, Mary Beth
author_facet Kehm, Rebecca D
Yang, Wan
Tehranifar, Parisa
Terry, Mary Beth
author_sort Kehm, Rebecca D
collection PubMed
description BACKGROUND: Studies have documented a temporal increase in incidence for several cancers in US young adults aged 25 to 39-years, including noncardia gastric cancer, colorectal cancer, and distant-stage breast cancer. To further characterize trends in young adults, we assessed age-specific and stage-specific incidence trends from 1975 to 2015, overall (all malignant cancers combined), and for 18 and 16 cancer sites in women and men, respectively. METHODS: We used US population-based data from the Surveillance, Epidemiology, and End Results Program to obtain overall and site-specific cancer incidence rates by sex and age group. We individually analyzed cancer sites with an incidence rate of at least 5 per 100 000 in 2015, accounting for greater than 90% of all cancer diagnoses. We estimated annual percent changes (APCs) using segment log-linear regression performed with joinpoint software; multiple permutation testing was used to identify inflection points. We forecasted overall cancer incidence through 2030 using age-period-cohort regression models. RESULTS: Based on trends occurring after the most recent joinpoint inflection point, overall cancer incidence increased by 1.15% (95% CI = 1.01% to 1.28%) per year in 25- to 39-year-old women and by 0.46% (95% CI = 0.17% to 0.75%) per year in 25- to 39-year-old men; APCs were of much lower magnitude in the older age groups (eg, 70- to 84-year-old women APC = −0.31%, 95% CI = −0.42% to −0.20%). We forecasted that overall cancer incidence will increase by an additional 11% by 2030 in 25- to 39-year-old women, and by an additional 12% in 25- to 39-year-old men. Ten of the 18 cancers assessed in 25- to 39-year-old women and 7 of the 16 cancers in 25- to 39-year-old men have been statistically significantly increasing over time. We found that the increase in incidence for young adults is stage specific for some cancers (eg, only nonlocalized breast cancer has increased in 25- to 39-year-old women). CONCLUSION: Cancer incidence is increasing in young adults, particularly in young women.
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spelling pubmed-66868482019-08-12 40 Years of Change in Age- and Stage-Specific Cancer Incidence Rates in US Women and Men Kehm, Rebecca D Yang, Wan Tehranifar, Parisa Terry, Mary Beth JNCI Cancer Spectr Article BACKGROUND: Studies have documented a temporal increase in incidence for several cancers in US young adults aged 25 to 39-years, including noncardia gastric cancer, colorectal cancer, and distant-stage breast cancer. To further characterize trends in young adults, we assessed age-specific and stage-specific incidence trends from 1975 to 2015, overall (all malignant cancers combined), and for 18 and 16 cancer sites in women and men, respectively. METHODS: We used US population-based data from the Surveillance, Epidemiology, and End Results Program to obtain overall and site-specific cancer incidence rates by sex and age group. We individually analyzed cancer sites with an incidence rate of at least 5 per 100 000 in 2015, accounting for greater than 90% of all cancer diagnoses. We estimated annual percent changes (APCs) using segment log-linear regression performed with joinpoint software; multiple permutation testing was used to identify inflection points. We forecasted overall cancer incidence through 2030 using age-period-cohort regression models. RESULTS: Based on trends occurring after the most recent joinpoint inflection point, overall cancer incidence increased by 1.15% (95% CI = 1.01% to 1.28%) per year in 25- to 39-year-old women and by 0.46% (95% CI = 0.17% to 0.75%) per year in 25- to 39-year-old men; APCs were of much lower magnitude in the older age groups (eg, 70- to 84-year-old women APC = −0.31%, 95% CI = −0.42% to −0.20%). We forecasted that overall cancer incidence will increase by an additional 11% by 2030 in 25- to 39-year-old women, and by an additional 12% in 25- to 39-year-old men. Ten of the 18 cancers assessed in 25- to 39-year-old women and 7 of the 16 cancers in 25- to 39-year-old men have been statistically significantly increasing over time. We found that the increase in incidence for young adults is stage specific for some cancers (eg, only nonlocalized breast cancer has increased in 25- to 39-year-old women). CONCLUSION: Cancer incidence is increasing in young adults, particularly in young women. Oxford University Press 2019-06-10 /pmc/articles/PMC6686848/ /pubmed/31414075 http://dx.doi.org/10.1093/jncics/pkz038 Text en © The Author(s) 2019. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contactjournals.permissions@oup.com.
spellingShingle Article
Kehm, Rebecca D
Yang, Wan
Tehranifar, Parisa
Terry, Mary Beth
40 Years of Change in Age- and Stage-Specific Cancer Incidence Rates in US Women and Men
title 40 Years of Change in Age- and Stage-Specific Cancer Incidence Rates in US Women and Men
title_full 40 Years of Change in Age- and Stage-Specific Cancer Incidence Rates in US Women and Men
title_fullStr 40 Years of Change in Age- and Stage-Specific Cancer Incidence Rates in US Women and Men
title_full_unstemmed 40 Years of Change in Age- and Stage-Specific Cancer Incidence Rates in US Women and Men
title_short 40 Years of Change in Age- and Stage-Specific Cancer Incidence Rates in US Women and Men
title_sort 40 years of change in age- and stage-specific cancer incidence rates in us women and men
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686848/
https://www.ncbi.nlm.nih.gov/pubmed/31414075
http://dx.doi.org/10.1093/jncics/pkz038
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