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Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture
SNP-heritability is a fundamental quantity in the study of complex traits. Recent works have shown that existing methods to estimate genome-wide SNP-heritability yield biases when their assumptions are violated. While various approaches have been proposed to account for frequency- and LD-dependent g...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686906/ https://www.ncbi.nlm.nih.gov/pubmed/31358995 http://dx.doi.org/10.1038/s41588-019-0465-0 |