Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture

SNP-heritability is a fundamental quantity in the study of complex traits. Recent works have shown that existing methods to estimate genome-wide SNP-heritability yield biases when their assumptions are violated. While various approaches have been proposed to account for frequency- and LD-dependent g...

Descripción completa

Detalles Bibliográficos
Autores principales: Hou, Kangcheng, Burch, Kathryn S., Majumdar, Arunabha, Shi, Huwenbo, Mancuso, Nicholas, Wu, Yue, Sankararaman, Sriram, Pasaniuc, Bogdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686906/
https://www.ncbi.nlm.nih.gov/pubmed/31358995
http://dx.doi.org/10.1038/s41588-019-0465-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686906/
https://www.ncbi.nlm.nih.gov/pubmed/31358995
http://dx.doi.org/10.1038/s41588-019-0465-0

Ejemplares similares