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Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture

SNP-heritability is a fundamental quantity in the study of complex traits. Recent works have shown that existing methods to estimate genome-wide SNP-heritability yield biases when their assumptions are violated. While various approaches have been proposed to account for frequency- and LD-dependent g...

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Detalles Bibliográficos
Autores principales:	Hou, Kangcheng, Burch, Kathryn S., Majumdar, Arunabha, Shi, Huwenbo, Mancuso, Nicholas, Wu, Yue, Sankararaman, Sriram, Pasaniuc, Bogdan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686906/ https://www.ncbi.nlm.nih.gov/pubmed/31358995 http://dx.doi.org/10.1038/s41588-019-0465-0

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