Empowering therapeutic antibodies with IFN-α for cancer immunotherapy

Type 1 IFNs stimulate secretion of IP-10 (CXCL10) which is a critical chemokine to recruit effector T cells to the tumor microenvironment and IP-10 knockout mice exhibit a phenotype with compromised effector T cell generation and trafficking. Type 1 IFNs also induce MHC class 1 upregulation on tumor...

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Detalles Bibliográficos
Autores principales: Guo, Jun, Xiao, Yu, Iyer, Ramesh, Lu, Xin, Lake, Marc, Ladror, Uri, Harlan, John, Samanta, Tanushree, Tomlinson, Medha, Bukofzer, Gail, Donawho, Cherrie, Shoemaker, Alex, Huang, Tzu-Hsuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687177/
https://www.ncbi.nlm.nih.gov/pubmed/31393905
http://dx.doi.org/10.1371/journal.pone.0219829

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687177/
https://www.ncbi.nlm.nih.gov/pubmed/31393905
http://dx.doi.org/10.1371/journal.pone.0219829

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